Imaging Intelligence LaboratorySeoul National University
Imaging Intelligence LaboratorySeoul National University

seungahlee@snu.ac.kr
Department of Mechanical Engineering, Seoul National University

Publications

20268

  1. Physics-guided neural network for single-shot real-time dynamic speckle imaging 

    Recovers blood-flow and static-scattering maps from a single rolling-shutter speckle frame with a physics-guided neural network.

    Byun, S., Yi, C., Bae, D., Kang, Y.G., Kim, J., Chang, H., & Lee, S.A.

    Journal of Physics: Photonics, 8(4), 045002doi:10.1088/2515-7647/ae99baDynamic speckle imaging

  2. Integrated Forward–Inverse Network for Lensless Image Reconstruction 

    Reconstructs sharp images from lensless cameras by keeping the camera model inside every network block.

    Bae, D., Jung, J., Kang, Y.G., Lee, K.C., Kim, T., Kim, J., Byun, S., Park, J., & Lee, S.A.

    Computer Vision – ECCV 2026 (Lecture Notes in Computer Science), pp. 628–645doi:10.1007/978-3-032-37517-9_35arXiv:2607.04608Lensless camerasConference

  3. Disposable Endoscope Cap Maintaining Clear Surgical Visualization under Fogging and Fouling 

    Son, K., Lee, Y., Lee, K., Jo, Y., Lee, Y., Lee, S.H., Seo, M.Y., Lee, J.S., Lee, S.A., Hong, S.N., Lee, S.H.*, & Seo, J.*

    ACS Applied Materials & Interfaces, 18(25), 34821–34834doi:10.1021/acsami.6c04312

  4. Geometry-aware phase compensation for sampling-efficient angular spectrum method 

    Simulates light through thick optics in fewer steps, to design masks that work across wide angles.

    Kang, Y.G., Bae, D., Jung, J., Byun, S., Ahn, H.J., Chang, H., Park, J., Lee, H., & Lee, S.A.

    Optics Express, 34(8), 15244doi:10.1364/OE.586512Lensless cameras

  5. Computational space-bandwidth product expansion via multiscale aperture synthesis and wavefront engineering 

    Kang, Y.G., Chae, H., & Lee, S.A.

    Advanced Imaging, 3(3), 033001doi:10.3788/AI.2026.30001Computational microscopyCommentary

  6. Pupil Plane Multiplexing for Vectorial Fourier Ptychography 

    Maps birefringence and phase at high resolution with one monochrome camera and a split polarizer.

    Chae, H., Lee, K., Kang, Y.G., Yoon, H., Lee, K.C., & Lee, S.A.

    Laser & Photonics Reviews, 20(9), e02183doi:10.1002/lpor.202502183Computational microscopy

  7. Semi-supervised virtual staining using learned-illumination Fourier ptychography for high-speed label-free histopathology 

    Turns unstained tissue slides into virtual H&E in seconds using 16 learned LED illumination patterns.

    Lee, K.C., Chae, H., Kim, J., Kreiss, L., Kim, H., Kang, Y.G., Zhou, K.C., Chaware, A., Kim, K., Xu, S., Kang, S., Bang, G., Cho, N.H., Hwang, D., Horstmeyer, R., & Lee, S.A.

    Journal of Physics: Photonics, 8(1), 015025doi:10.1088/2515-7647/ae270fComputational microscopyVirtual staining

  8. Fidelity-preserving zero-shot diffusion models for highly ill-posed inverse problems in lensless imaging 

    Lee, H., Mun, D.J., Lee, H., Lee, K.C., Hong, S., Kim, G., Lee, S.A., & Chun, S.Y.

    Image and Vision Computing, 165, 105786doi:10.1016/j.imavis.2025.105786Lensless cameras

20253

  1. Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy 

    Kreiss, L., Wu, M., Wayne, M., Xu, S., McKee, P., Dwamena, D., Kim, K., Lee, K.C., Cowdrick, K.R., Liu, W., Ülkü, A., Harfouche, M., Yang, X., Cook, C., Lee, S.A., Buckley, E., Bruschini, C., Charbon, E., Huettel, S., & Horstmeyer, R.

    Neurophotonics, 12(2), 025007doi:10.1117/1.NPh.12.2.025007Dynamic speckle imaging

  2. Single-shot Fourier ptychography using polarization-encoded illumination 

    Packs a full Fourier ptychography dataset into one camera frame, for phase video at 75 fps.

    Yoon, H., Chae, H., Lee, K.C., Lee, K., & Lee, S.A.

    Applied Physics Letters, 126(12), 123702doi:10.1063/5.0248101Computational microscopy

  3. Conductive-bridge interlayer contacts for two-dimensional optoelectronic devices 

    Jang, J., Hong, J.P., Kim, S.J., Ahn, J., Yu, B.S., Han, J., Lee, K., Ha, A., Yoon, E., Kim, W., Jo, S., Ko, H.W., Yoon, S.K., Taniguchi, T., Watanabe, K., Baek, H., Kim, D.Y., Lee, K., Mun, S., Lee, K.H., Park, S., Kim, K., Song, Y.J., Lee, S.A., Kim, H.J., Shim, J.W., Wang, G., Kang, J.H., Park, M.C., & Hwang, D.K.

    Nature Electronics, 8(4), 298–308doi:10.1038/s41928-025-01339-9

20247

  1. Restoring H&E stain in faded slides via phase-to-color virtual staining in near-infrared 

    Restores the color of faded H&E slides digitally, from near-infrared phase images of the tissue.

    Chae, H., Kim, J., Jeon, J., Lee, K., Lee, K.C., Choi, J.U., Kang, S., Choi, S., Bang, G., Lee, J.H., Park, E., Cho, N.H., & Lee, S.A.

    APL Photonics, 9(10), 106112doi:10.1063/5.0226277Computational microscopyVirtual staining

  2. Anisotropic regularization for sparsely sampled and noise-robust Fourier ptychography 

    Lee, K.C., Chae, H., Xu, S., Lee, K., Horstmeyer, R., Lee, S.A., & Hong, B.W.

    Optics Express, 32(14), 25343–25361doi:10.1364/OE.529023Computational microscopy

  3. High-resolution display screen as programmable illumination for Fourier ptychography 

    Lee, K., Lee, K.C., Jung, J., Chae, H., & Lee, S.A.

    Optics and Lasers in Engineering, 177, 108121doi:10.1016/j.optlaseng.2024.108121Computational microscopy

  4. Computational 3D topographic microscopy from terabytes of data per sample 

    Zhou, K.C., Harfouche, M., Zheng, M., Jönsson, J., Lee, K.C., Kim, K., Appel, R., Reamey, P., Doman, T., Saliu, V., Horstmeyer, G., Lee, S.A., & Horstmeyer, R.

    Journal of Big Data, 11(1), 62doi:10.1186/s40537-024-00901-0Computational microscopy

  5. Rolling shutter speckle plethysmography for quantitative cardiovascular monitoring 

    Measures blood flow and blood volume pulses at the fingertip with an ordinary rolling-shutter camera.

    Lee, Y., Byun, S., Yi, C., Jung, J., & Lee, S.A.

    Biomedical Optics Express, 15(3), 1540–1552doi:10.1364/BOE.511755Dynamic speckle imaging

  6. Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging 

    Xu, S., Yang, X., Ritter, P., Dai, X., Lee, K.C., Kreiss, L., Zhou, K.C., Kim, K., Chaware, A., Neff, J., Glass, C., Lee, S.A., Friedrich, O., & Horstmeyer, R.

    Advanced Photonics, 6(2), 026004doi:10.1117/1.AP.6.2.026004Computational microscopy

  7. Improvements and validation of a spatiotemporal speckle correlation model for rolling shutter speckle imaging 

    Yi, C., Byun, S., Lee, Y., & Lee, S.A.

    Biomedical Optics Express, 15(2), 1253–1267doi:10.1364/BOE.514497Dynamic speckle imaging

20234

  1. Laser-assisted recovery of on-chip phage viral DNA for phage fluorescence immunoassay microchip 

    Chang, S., Kim, S., Lee, D., Lee, S.A., Chung, J., Kwon, S., & Kim, J.

    BioChip Journal, 17(4), 431–438doi:10.1007/s13206-023-00117-z

  2. Digital staining in optical microscopy using deep learning - a review 

    Kreiss, L., Jiang, S., Li, X., Xu, S., Zhou, K.C., Lee, K.C., Mühlberg, A., Kim, K., Chaware, A., Ando, M., Barisoni, L., Lee, S.A., Zheng, G., Lafata, K.J., Friedrich, O., & Horstmeyer, R.

    PhotoniX, 4, 34doi:10.1186/s43074-023-00113-4Computational microscopyVirtual stainingReview

  3. Aperture-encoded snapshot hyperspectral imaging with a lensless camera 

    Captures a 410–800 nm hyperspectral image stack in one monochrome lensless snapshot.

    Kim, T., Lee, K.C., Baek, N., Chae, H., & Lee, S.A.

    APL Photonics, 8(6), 066109doi:10.1063/5.0150797Lensless cameras

  4. Design and single-shot fabrication of lensless cameras with arbitrary point spread functions 

    Prints a phase mask for any chosen point-spread function in a single lithography exposure.

    Lee, K.C., Bae, J., Baek, N., Jung, J., Park, W., & Lee, S.A.

    Optica, 10(1), 72–80doi:10.1364/OPTICA.466072Lensless cameras

20225

  1. Single-shot temporal speckle correlation imaging using rolling shutter image sensors 

    Maps blood flow from a single camera frame by reading laser speckle row by row.

    Yi, C., Jung, J., Im, J., Lee, K.C., Chung, E., & Lee, S.A.

    Optica, 9(11), 1227–1237doi:10.1364/OPTICA.465361Dynamic speckle imaging

  2. Lensless polarization camera for single-shot full-Stokes imaging 

    Baek, N., Lee, Y., Kim, T., Jung, J., & Lee, S.A.

    APL Photonics, 7(11), 116107doi:10.1063/5.0120465Lensless cameras

  3. EuglPollock: Rethinking Interspecies Collaboration through Art Making 

    People and light-steered Euglena cells make one-of-a-kind artworks together under a microscope.

    Lee, K., Jang, Y.K., Jung, J., Kim, D.H., Lee, H.J., & Lee, S.A.

    Proceedings of the 30th ACM International Conference on Multimedia, pp. 1077–1084doi:10.1145/3503161.3548151Interactive biologyConference

  4. Micro-HBI: Human-Biology Interaction With Living Cells, Viruses, and Molecules 

    Lee, S.A., & Riedel-Kruse, I.H.

    Frontiers in Computer Science, 4, 849887doi:10.3389/fcomp.2022.849887Interactive biologyReview

  5. Fabrication of Integrated Lensless Cameras via UV-Imprint Lithography 

    Lee, Y., Chae, H., Lee, K.C., Baek, N., Kim, T., Jung, J., & Lee, S.A.

    IEEE Photonics Journal, 14(2), 1–8doi:10.1109/JPHOT.2022.3157373Lensless cameras

20216

  1. Noniterative sub-pixel shifting super-resolution lensless digital holography 

    Lee, H., Kim, J., Kim, J., Jeon, P., Lee, S.A., & Kim, D.

    Optics Express, 29(19), 29996–30006doi:10.1364/OE.433719Computational microscopyLensless cameras

  2. Machine learning-based leaky momentum prediction of plasmonic random nanosubstrate 

    Kim, J., Lee, H., Im, S., Lee, S.A., Kim, D., & Toh, K.A.

    Optics Express, 29(19), 30625–30636doi:10.1364/OE.437939

  3. ReMember: Using Biosignals to Recall Memories of Companion Animals 

    Yi, C., Bae, J., Baek, N., Jung, J., Hur, S., Lee, H.J., & Lee, S.A.

    Proceedings of the ACM on Computer Graphics and Interactive Techniques, 4(2), 1–7doi:10.1145/3465614Interactive biology

  4. Microbe-HCI: Introduction and Directions for Growth 

    Kim, R., Pataranutaporn, P., Forman, J., Lee, S.A., Riedel-Kruse, I.H., Alistar, M., Lazaro Vasquez, E.S., Vega, K., van Dierendonck, R., Gome, G., Zuckerman, O., Vujic, A., Kong, D.S., Maes, P., Ishii, H., Sra, M., & Poslad, S.

    Extended Abstracts of the 2021 CHI Conference on Human Factors in Computing Systems, pp. 1–4doi:10.1145/3411763.3450408Interactive biologyConference

  5. A Smartphone-Based Fourier Ptychographic Microscope Using the Display Screen for Illumination 

    Turns a smartphone's screen, camera and processor into a wide-field, high-resolution microscope.

    Lee, K.C., Lee, K., Jung, J., Lee, S.H., Kim, D., & Lee, S.A.

    ACS Photonics, 8(5), 1307–1315doi:10.1021/acsphotonics.1c00350Computational microscopy

  6. Disordered Nanocomposite Islands for Nanospeckle Illumination Microscopy in Wide‐Field Super‐Resolution Imaging 

    Yoo, H., Lee, H., Rhee, W.J., Moon, G., Lee, C., Lee, S.A., Shin, J.S., & Kim, D.

    Advanced Optical Materials, 9(15), 2100211doi:10.1002/adom.202100211Computational microscopy

20204

  1. Surface Plasmon Localization-Based Super-resolved Raman Microscopy 

    Lee, H., Kang, K., Mochizuki, K., Lee, C., Toh, K.A., Lee, S.A., Fujita, K., & Kim, D.

    Nano Letters, 20(12), 8951–8958doi:10.1021/acs.nanolett.0c04219Computational microscopy

  2. Lensless Imaging with an End-to-End Deep Neural Network 

    Bae, D., Jung, J., Baek, N., & Lee, S.A.

    2020 IEEE International Conference on Consumer Electronics – Asia (ICCE-Asia), pp. 1–5doi:10.1109/icce-asia49877.2020.9276865Lensless camerasConference

  3. MicroAquarium: An Immersive and Interactive Installation with Living Microorganisms 

    Lee, K., Jung, J., & Lee, S.A.

    Extended Abstracts of the 2020 CHI Conference on Human Factors in Computing Systems, pp. 1–4doi:10.1145/3334480.3383164Interactive biologyConference

  4. Pac-Euglena: A Living Cellular Pac-Man Meets Virtual Ghosts 

    Lam, A.T., Griffin, J., Loeun, M.A., Cira, N.J., Lee, S.A., & Riedel-Kruse, I.H.

    Proceedings of the 2020 CHI Conference on Human Factors in Computing Systems, pp. 1–13doi:10.1145/3313831.3376378Interactive biologyConference

20191

  1. First-hand, immersive full-body experiences with living cells through interactive museum exhibits 

    Lam, A.T., Ma, J., Barr, C., Lee, S.A., White, A.K., Yu, K., & Riedel-Kruse, I.H.

    Nature Biotechnology, 37(10), 1238–1241doi:10.1038/s41587-019-0272-2Interactive biology

Pre-grouppublications (2008–2017)15

  1. Device and programming abstractions for spatiotemporal control of active micro-particle swarms 

    Lam, A.T., Samuel-Gama, K.G., Griffin, J., Loeun, M., Gerber, L.C., Hossain, Z., Cira, N.J., Lee, S.A., & Riedel-Kruse, I.H.

    Lab on a Chip, 17(8), 1442–1451 (2017)doi:10.1039/C7LC00131BInteractive biologyBefore IIL

  2. LudusScope: accessible interactive smartphone microscopy for life-science education 

    Kim, H., Gerber, L.C., Chiu, D., Lee, S.A., Cira, N.J., Xia, S.Y., & Riedel-Kruse, I.H.

    PLOS ONE, 11(10), e0162602 (2016)doi:10.1371/journal.pone.0162602Interactive biologyComputational microscopyBefore IIL

  3. Trap it! A playful human-biology interaction for a museum installation 

    Lee, S.A., Bumbacher, E., Chung, A.M., Cira, N., Walker, B., Park, J.Y., Starr, B., Blikstein, P., & Riedel-Kruse, I.H.

    Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems (CHI), pp. 2593–2602 (2015)doi:10.1145/2702123.2702220Interactive biologyConferenceBefore IIL

  4. Tangible interactive microbiology for informal science education 

    Lee, S.A., Chung, A.M., Cira, N., & Riedel-Kruse, I.H.

    Proceedings of the Ninth International Conference on Tangible, Embedded, and Embodied Interaction (TEI), pp. 273–280 (2015)doi:10.1145/2677199.2680561Interactive biologyConferenceBefore IIL

  5. A smartphone-based chip-scale microscope using ambient illumination 

    Lee, S.A., & Yang, C.

    Lab on a Chip, 14(16), 3056–3063 (2014)doi:10.1039/C4LC00523FComputational microscopyLensless camerasBefore IIL

  6. Imaging and identification of waterborne parasites using a chip-scale microscope 

    Lee, S.A., Erath, J., Zheng, G., Ou, X., Willems, P., Eichinger, D., Rodriguez, A., & Yang, C.

    PLOS ONE, 9(2), e89712 (2014)doi:10.1371/journal.pone.0089712Computational microscopyLensless camerasBefore IIL

  7. Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality 

    Jung, J.H., Han, C., Lee, S.A., Kim, J., & Yang, C.

    Lab on a Chip, 14(19), 3781–3789 (2014)doi:10.1039/C4LC00790EComputational microscopyBefore IIL

  8. Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor 

    Lee, S.A., Ou, X., Lee, J.E., & Yang, C.

    Optics Letters, 38(11), 1817–1819 (2013)doi:10.1364/OL.38.001817Computational microscopyLensless camerasBefore IIL

  9. On-chip continuous monitoring of motile microorganisms on an ePetri platform 

    Lee, S.A., Zheng, G., Mukherjee, N., & Yang, C.

    Lab on a Chip, 12(13), 2385–2390 (2012)doi:10.1039/C2LC40090AComputational microscopyLensless camerasBefore IIL

  10. Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis 

    Lee, S.A., Leitao, R., Zheng, G., Yang, S., Rodriguez, A., & Yang, C.

    PLOS ONE, 6(10), e26127 (2011)doi:10.1371/journal.pone.0026127Computational microscopyLensless camerasBefore IIL

  11. The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM) 

    Zheng, G., Lee, S.A., Antebi, Y., Elowitz, M.B., & Yang, C.

    Proceedings of the National Academy of Sciences, 108(41), 16889–16894 (2011)doi:10.1073/pnas.1110681108Computational microscopyLensless camerasBefore IIL

  12. Sub-pixel resolving optofluidic microscope for on-chip cell imaging 

    Zheng, G.*, Lee, S.A.*, Yang, S.*, & Yang, C.

    Lab on a Chip, 10(22), 3125–3129 (2010)doi:10.1039/C0LC00213EComputational microscopyLensless camerasBefore IIL

  13. Optofluidic encapsulation and manipulation of silicon microchips using image processing based optofluidic maskless lithography and railed microfluidics 

    Chung, S.E., Lee, S.A., Kim, J., & Kwon, S.

    Lab on a Chip, 9(19), 2845–2850 (2009)doi:10.1039/B903760HBefore IIL

  14. Three-dimensional fabrication of heterogeneous microstructures using soft membrane deformation and optofluidic maskless lithography 

    Lee, S.A., Chung, S.E., Park, W., Lee, S.H., & Kwon, S.

    Lab on a Chip, 9(12), 1670–1675 (2009)doi:10.1039/B819999JBefore IIL

  15. Guided and fluidic self-assembly of microstructures using railed microfluidic channels 

    Chung, S.E., Park, W., Shin, S., Lee, S.A., & Kwon, S.

    Nature Materials, 7(7), 581–587 (2008)doi:10.1038/nmat2208Before IIL

Patents

22 patents

In the media

Press coverage

News articles, press releases and journal features about the laboratory’s work and Seung Ah Lee’s earlier research.

Laboratory (2018–)

  1. Aug 20262 articles

    SNU–Caltech Innovation Research Center for Semiconductor Inspection and Metrology

    Selected for the Top-tier International Research Institution Collaboration Hub program of the Ministry of Science and ICT (10 years). The center is led by Prof. Seung Ah Lee's group at Seoul National University with Caltech as the partner institution. KAIST and UC Berkeley take part in microscopy from the extreme ultraviolet to the near infrared, and the Paul Scherrer Institute (PSI, Switzerland) in EUV processes and precision metrology.

  2. Jun 20261 article

    IFIN lensless image reconstruction accepted at ECCV 2026

    Department news on the integrated forward–inverse network for lensless cameras.

    Bae et al., ECCV 2026

  3. May 20252 articles

    Joining Seoul National University

    New-faculty introduction and laboratory interview in the Department of Mechanical Engineering news.

  4. Jun 20231 article

    Snapshot hyperspectral imaging with a lensless camera

    Featured in AIP Scilight and selected as an Editor’s Pick in APL Photonics.

    T. Kim et al., APL Photonics 2023

  5. Mar 20232 articles

    Art–science collaboration at Ulsan Art Museum

    Exhibition “Twisted Data” (뒤틀린 데이터), March–June 2023: a lensless-camera work made with media artist Jaehyuck Bae (Team VOID).

  6. Jan 20232 articles

    Design and single-shot fabrication of lensless cameras with arbitrary PSFs

    Cover article of Optica (January 2023) and Yonsei University press release, with Prof. Wook Park (Kyung Hee University).

    K. C. Lee et al., Optica 2023

  7. Jan 20232 articles

    Smartphone microscope at CES 2023

    Yonsei University College of Engineering exhibition booth at CES 2023, Las Vegas.

  8. Dec 20222 articles

    Blood-flow speed from a single speckle image

    National Research Foundation of Korea press release on rolling-shutter speckle imaging of cerebral blood flow.

    C. Yi et al., Optica 2022

  9. Nov 20211 article

    ReMember: biosignals to recall memories of companion animals

    Interview with Changyoon Yi on the ACM SIGGRAPH blog about the SIGGRAPH 2021 art paper.

    C. Yi et al., SIGGRAPH 2021

Journal covers and highlights

Earlier work by Seung Ah Lee

Seoul National University, Caltech and Stanford, before the laboratory

  1. Oct 20192 articles

    Full-body interaction with living cells at the Exploratorium

    Stanford press release on the museum exhibit developed in the Riedel-Kruse lab.

    A. T. Lam et al., Nat. Biotechnol. 2019

  2. Oct 20162 articles

    LudusScope: a smartphone microscope for playing with microbes

    Stanford press release on the 3D-printed interactive smartphone microscope for life-science education.

    H. Kim et al., PLOS ONE 2016

  3. Apr 20152 articles

    Interactive biotechnology: biotic games and a museum kiosk

    Stanford press release; the museum kiosk project was led by Seung Ah Lee as a postdoctoral fellow.

    S. A. Lee et al., CHI 2015

  4. Oct 20112 articles

    The ePetri dish: a smart Petri dish on an image sensor

    Caltech press release on the on-chip cell-imaging platform built from a smartphone image sensor and LEGO parts.

    G. Zheng, S. A. Lee et al., PNAS 2011

  5. Oct 20101 article

    A lens-free sub-pixel resolving optofluidic microscope

    MIT Technology Review article on the chip-scale microscope for low-cost diagnostics.

    G. Zheng, S. A. Lee, S. Yang et al., Lab Chip 2010

Journal covers and highlights